The Big C conta a história de Cathy (Linney), uma reprimida esposa suburbana de Connecticut que, ao ser diagnosticada com câncer, decide retomar as rédeas de sua vida. Platt faz o bem intencionado, porém imaturo, marido da personagem, enquanto Sidibe será uma aluna espertalhona na classe de Cathy.

1ª Temporada

1×01 – Pilot
1×02 – Summertime
1×03 – There’s No C In Team
1×04 – Playing the Cancer Car
1×05 – Blue-Eyed Iris
1×06 – Taking Lumps
1×07 – Two for the Road
1×08 – Happy Birthday, Cancer
1×09 – The Ecstacy and the Agony
1×10 – Divine Intervention
1×11 – New Beginnings
1×12 – Everything That Rises
1×13 – Taking the Plunge (Season Finale)

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2ª Temporada

2×01 – Losing Patients
2×02 – Musical Chairs
2×03 – Sexual Healing
2×04 – Boo!
2×05 – Cats and Dogs
2×06 – The Little c
2×07 – Goldilocks and the Bear
2×08 – The Last Thanksgiving
2×09 – A Little Death
2×10 – How Do You Feel?
2×11 – Fight or Flight
2×12 – The Darkest Day
2×13 – Crossing the Line (Season Finale)

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3ª Temporada

3×01 – Thin Ice
3×02 – What’s Your Story?
3×03 – Bundle of Joy
3×04 – Family Matters
3×05 – Face Off
3×06 – Life Rights
3×07 – How Bazaar
3×08 – Killjoy
3×09 – Vaya Con Dios
3×10 – Fly Away (Season Finale)

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